Introduction
Emeset tablets have been used to prevent or treat nausea and vomiting caused by cancer treatments such as chemotherapy and radiotherapy, which are often used to kill cancer cells. It is also used to relieve the symptoms post-operative vomiting and nausea after surgery. Emeset helps to regulate and handle the onset of nausea and vomiting after cancer treatment and surgery, but it is ineffective at preventing vomiting and nausea caused by other causes, such as motion sickness, which is caused by a different mechanism.
Drug Activity
Emeset contains ondansetron, a highly selective and potent 5HT3 receptor antagonist used as an antiemetic to control nausea and vomiting related to cancer chemotherapy and radiotherapy, as well as to inhibit postoperative nausea and vomiting. Chemotherapy, radiotherapy, and surgery are thought to cause the release of serotonin (5HT) from small intestine cells, which stimulates 5HT3 receptors found on vagal nerves in the intestines. Serotonin stimulation of these nerve endings sends nerve messages to the vomiting center in the brain (a complex area of neuronal networks) that causes the vomiting reflex. Ondansetron is thought to work by preventing nerve messages from the intestines from reaching the vomiting center in the brain. There are several 5HT3 receptors with in chemoreceptor trigger zone (CTZ) of the postsynaptic membrane in the brain, which initiates the vomiting reflex by transmitting nerve signals to the vomiting center. Ondansetron in Emeset is thought to block the 5HT3 receptors in the CTZ, preventing stimulation of the vomiting center of the brain. Emeset ondansetron blocks the 5HT3 receptors located in the intestine’s peripheral nervous system and the brain’s central nervous system. Ondansetron in Emeset has a dual effect in that it inhibits vomiting induced by chemotherapy and radiotherapy, as well as post-surgery vomiting, and it also helps relieve nausea.
Components
Emeset tablets contain ondansetron hydrochloride, an antiemetic often used to treat illnesses caused by chemotherapy and radiotherapy, as well as to prevent postoperative vomiting and nausea.
Chemotherapy and radiotherapy are cytotoxic treatment methods that trigger the release of serotonin (5HT) from small intestinal cells, which stimulates the 5HT3 receptors on the vagal nerves in the intestines. Serotonin stimulation of these nerve endings sends nerve signals to the vomiting center in the brain (a sophisticated area of brain circuits) that causes the vomiting reflex. Then there are 5HT3 receptors in the chemoreceptor trigger zone (CTZ) of the postsynaptic membrane in the brain, where the vomiting reflex is initiated by serotonin stimulation of 5HT3 receptors, which sends nerve messages to the vomiting centre. Emeset contains ondansetron, a potent and highly selective 5HT3 receptor antagonist, and its antiemetic action is thought to be due to the inhibition of 5HT3 receptors inside the peripheral nerves of the digestive system and also in the nerve cells of the CTZ in the brain. Ondansetron’s dual-action in Emeset inhibits nausea and vomiting caused by radiotherapy and chemotherapy.
Side Effects
A significant proportion of side effects are not serious but will go away whenever your body adapts to the medication. Consult a doctor if they persist or if you are concerned. Emeset commonly causes the following side effects:
- Incontinence
- Diarrhea
- Exhaustion
- Migraine
- Warmth or Flushing Sensation
- Hypertension (Low Blood Pressure)
- Hiccups
- Heart Arrhythmias (Irregular Heart Beat)
- Chest Ache
Who Should Avoid?
Individuals should avoid taking Emeset tablets if they are:
- Allergic to ondansetron or other specific 5HT3 receptor antagonists, or if they are allergic to any of the ingredients in Emeset.
- A patient suffering from liver disease
- A patient suffering from subacute bowel obstructions (constipation).
Emeset-Interacting Medications
Numerous medicines interact with Emeset and should be avoided or taken only with the doctor’s approval:
- Anticonvulsants like phenytoin and carbamazepine, as well as antibiotics like rifampicin, have been shown to have an effect on Emeset.
- Emeset affects drugs such as Tramadol and other analgesics.
How Should It Be Consumed?
Emeset can be taken with a cup of water either with or without food well before the start of treatment to prevent nausea and vomiting after chemotherapy or radiotherapy. The dose is predominantly determined according to how emetogenic (nausea/vomiting-inducing) the procedure is and is usually taken 30 minutes to 2 hours before treatment, then twelve hours later, then twice daily for 5 days after treatment. Emeset will be given to patients an hour prior to actually injecting anesthesia to prevent postsurgical nausea and vomiting.
Emeset tablets are only used to prevent nausea and vomiting caused by chemotherapy, radiotherapy, or surgery.
Advice on Safety
- Consuming alcohol while taking Emeset has no negative side effects.
- Emeset is generally thought to be safe to use while pregnant. Animal studies have revealed that there are few or no negative effects on the developing baby; nevertheless, human studies are scarce.
- Emeset is most likely safe to use while breastfeeding. According to the limited human data, the drug poses no substantial risk to the baby.
- The ability to drive after consuming Emeset is usually unaffected.
- Emeset is not harmful to patients with renal impairment. Emeset dose adjustment is generally not recommended. However, if you have underlying kidney disease, you should notify your doctor.
- There is relatively little information about the use of Emeset in patients with liver disease, and further research is needed; however, it is best to consult a doctor before taking it.